Established in memory of the famous revolutionary leader Thanthai Periyar, this museum is dedicated to Science and Technology. Scientific aspects are explained through various models in different galleries in Life Science Gallery, Energy Gallery, Transport Gallery, Physical Science Gallery, Ocean Gallery, Mirrors Gallery, and Heart Gallery. It has a Children's Corner, 3 D theatre, and one wing of this museum contains Birla Planetarium.

The museum is opened from 10 a.m. To 5:45 p.m daily and closed on Republic Day, Independence Day and on Gandhi Jayanthi.